Mei-P26 Mediates Tissue-Specific Responses to the Brat Tumor Suppressor and the dMyc Proto-Oncogene in Drosophila
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چکیده
منابع مشابه
Mei-P26 mediates tissue-specific responses to the Brat tumor suppressor and the dMyc proto-oncogene in Drosophila.
TRIM-NHL proteins are a family of translational regulators that control cell growth, proliferation, and differentiation during development. Drosophila Brat and Mei-P26 TRIM-NHL proteins serve as tumor suppressors in stem cell lineages and have been proposed to exert this action, in part, via the repression of the protooncogene dMyc. Here we analyze the role of Brat, Mei-P26, and dMyc in regulat...
متن کاملTRIM-NHL proteins are a family of translational regulators that control cell growth, proliferation and differentiation during development. In Drosophila, loss-of-function of two TRIM-NHL proteins, Brat and Mei- P26, leads to tumorous phenotypes in neural and germline stem cell
TRIM-NHL proteins are a family of translational regulators that control cell growth, proliferation and differentiation during development. In Drosophila, loss-of-function of two TRIM-NHL proteins, Brat and MeiP26, leads to tumorous phenotypes in neural and germline stem cell lineages, respectively. These phenotypes are caused, at least in part, by the expression of dMyc. Here, the authors show ...
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How stem cells generate both differentiating and self-renewing daughter cells is unclear. Here, we show that Drosophila larval neuroblasts-stem cell-like precursors of the adult brain-regulate proliferation by segregating the growth inhibitor Brat and the transcription factor Prospero into only one daughter cell. Like Prospero, Brat binds and cosegregates with the adaptor protein Miranda. In la...
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ژورنال
عنوان ژورنال: Genetics
سال: 2014
ISSN: 1943-2631
DOI: 10.1534/genetics.114.167502